Correlation Engine 2.0
Clear Search sequence regions

  • brain (1)
  • cellular (4)
  • gene (1)
  • gtpase (2)
  • humans (1)
  • Impdh (1)
  • mice (1)
  • neurons (1)
  • rna (2)
  • Tbc1d24 (7)
  • zeocin (1)
  • Sizes of these terms reflect their relevance to your search.

    It is not fully understood how enzymes are regulated in the tiny reaction field of a cell. Several enzymatic proteins form cytoophidia, a cellular macrostructure to titrate enzymatic activities. Here, we show that the epileptic encephalopathy-associated protein Tbc1d24 forms cytoophidia in neuronal cells both in vitro and in vivo. The Tbc1d24 cytoophidia are distinct from previously reported cytoophidia consisting of inosine monophosphate dehydrogenase (Impdh) or cytidine-5'-triphosphate synthase (Ctps). Tbc1d24 cytoophidia is induced by loss of cellular juvenescence caused by depletion of Gm14230, a juvenility-associated lncRNA (JALNC) and zeocin treatment. Cytoophidia formation is associated with impaired enzymatic activity of Tbc1d24. Thus, our findings reveal the property of Tbc1d24 to form cytoophidia to maintain neuronal cellular juvenescence.


    Takao Morimune, Ayami Tano, Yuya Tanaka, Haruka Yukiue, Takefumi Yamamoto, Ikuo Tooyama, Yoshihiro Maruo, Masaki Nishimura, Masaki Mori. Gm14230 controls Tbc1d24 cytoophidia and neuronal cellular juvenescence. PloS one. 2021;16(4):e0248517

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 33886577

    View Full Text