Isolation, structural characterization, biological activity, and application of Glycyrrhiza polysaccharides: Systematic review.

Zelalai Simayi, Parhat Rozi, Xiaojun Yang, Gulimire Ababaikeri, Wugulinisa Maimaitituoheti, Xiaowei Bao, Shengjun Ma, Guzalnur Askar, Nigary Yadikar

International journal of biological macromolecules 2021 Jul 31

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Glycyrrhiza, one of the most widely used Chinese herbal medicines, is a perennial plant with good medicinal value. Polysaccharides as one of the main bioactive components of Glycyrrhiza, mainly composed of arabinose, glucose, galactose, rhamnose, mannose, xylose, and galacturonic acid in different proportions and types of glycosidic bonds. Glycyrrhiza polysaccharides (GP) have many biological activities, such as anti-oxidation, immune regulation, anti-tumor, apoptosis, anti-microbial, anti-inflammatory and regulation of intestinal flora. In this paper, relevant articles on the isolations, structural characterizations, and biological activities of GP published in the last 15 years (2006-2020) were referred to for a systematic review of the species. A total of 947 articles were searched from the database including NCBI, Science Direct, Web of Science, and How Net, and 109 of them were cited on the summarization of the past scientific researches of the polysaccharides of Glycyrrhiza genus. We hope that this work may provide new insights for further study and development of Glycyrrhiza. Copyright © 2021. Published by Elsevier B.V.

Citation

Zelalai Simayi, Parhat Rozi, Xiaojun Yang, Gulimire Ababaikeri, Wugulinisa Maimaitituoheti, Xiaowei Bao, Shengjun Ma, Guzalnur Askar, Nigary Yadikar. Isolation, structural characterization, biological activity, and application of Glycyrrhiza polysaccharides: Systematic review. International journal of biological macromolecules. 2021 Jul 31;183:387-398