Acylphloroglucinol derivatives with ATP citrate lyase inhibitory activities from Syzygium oblatum Wall.

Jin-Chang Huang, Yi-Nan Liu, Yun-Hua Tao, Bai-Yu Chen, Chun Lei, Wei Fu, Jing-Ya Li, Xiao Hu, Ai-Jun Hou

Phytochemistry 2021 Jul

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Nine undescribed acylphloroglucinol derivatives, oblatones A-I, along with three known ones, were isolated from Syzygium oblatum. Their structures were determined on the basis of extensive spectroscopic analysis, including NMR and MS data interpretation. Oblatones A and B possess an alkylated chromanone scaffold featuring a hemiketal moiety. Oblatones C and D are the first acylphloroglucinol derivatives with an α,β-unsaturated ketone lipid chain. Some of the isolates showed inhibitory effects on ATP citrate lyase in vitro. The binding mode of oblatone A was predicted by molecular docking. Copyright © 2021 Elsevier Ltd. All rights reserved.

Citation

Jin-Chang Huang, Yi-Nan Liu, Yun-Hua Tao, Bai-Yu Chen, Chun Lei, Wei Fu, Jing-Ya Li, Xiao Hu, Ai-Jun Hou. Acylphloroglucinol derivatives with ATP citrate lyase inhibitory activities from Syzygium oblatum Wall. Phytochemistry. 2021 Jul;187:112765