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With the coming acceleration of global population aging, the incidence rate of cardio-cerebrovascular diseases (CVDs) is increasing. It has become the leading cause of human mortality. As a natural drug, borneol (BO) not only has anti-inflammatory, anti-oxidant, anti-apoptotic, anti-coagulant activities and improves energy metabolism but can also promote drugs to enter the target organs or tissues through various physiological barriers, such as the blood-brain barrier (BBB), mucous membrane, skin. Thus, it has a significant therapeutic effect on various CVDs, which has been confirmed in a large number of studies. However, the pharmacological actions and mechanisms of BO on CVDs have not been fully investigated. Hence, this review summarizes the pharmacological actions and possible mechanisms of BO, which provides novel ideas for the treatment of CVDs. Copyright © 2021 Elsevier Ltd. All rights reserved.


Songyu Liu, Yu Long, Shuang Yu, Dingkun Zhang, Qiyue Yang, Zhimin Ci, Mingquan Cui, Yulu Zhang, Jinyan Wan, Dan Li, Ai Shi, Nan Li, Ming Yang, Junzhi Lin. Borneol in cardio-cerebrovascular diseases: Pharmacological actions, mechanisms, and therapeutics. Pharmacological research. 2021 Apr 21;169:105627

PMID: 33892091

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