Prevalence of reduced carbon monoxide transfer factor in smokers with normal spirometry.

Timothy Cheung, Vicki Papanikolaou, Paul Finlay, Theresa Yong, Martin MacDonald, Bruce R Thompson, Philip G Bardin, Paul T King

Respiratory medicine 2021 Jun

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We report the prevalence of reduced levels of carbon monoxide transfer factor (TLCO) in middle-aged current or ex-smokers with normal spirometry. Spirometry and TLCO measurements were performed and we identified 391 subjects aged 40-60 years, with a significant smoking history and normal spirometry. In this group, 96 subjects (24%) had TLCO measuremements below the lower limit of normal when using the newly established Global Lung Initiative (GLI) reference equations. The measurement of TLCO should be considered as part of the standard assessment of smokers. Copyright © 2021 Elsevier Ltd. All rights reserved.

Citation

Timothy Cheung, Vicki Papanikolaou, Paul Finlay, Theresa Yong, Martin MacDonald, Bruce R Thompson, Philip G Bardin, Paul T King. Prevalence of reduced carbon monoxide transfer factor in smokers with normal spirometry. Respiratory medicine. 2021 Jun;182:106422