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    To investigate reciprocal regulation between Fur and two RyhB homologs in Yersinia pestis( Y. pestis), as well as the roles of RyhBs in biofilm formation. Regulatory relationships were assessed by a combination of colony morphology assay, primer extension, electrophoretic mobility shift assay and DNase I footprinting. Fur bound to the promoter-proximal DNA regions of ryhB1 and ryhB2 to repress their transcription, while both RyhB1 and RyhB2 repressed the expression of Fur at the post-transcriptional level. In addition, both RyhB1 and RyhB2 positively regulated Y. pestis biofilm exopolysaccharide (EPS) production and the expression of hmsHFRS and hmsT. Fur and the two RyhB homologs exert negative reciprocal regulation, and RyhB homologs have a positive regulatory effect on biofilm formation in Y. pestis. Copyright © 2021 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.


    Bin Ni, Hai Sheng Wu, You Quan Xin, Qing Wen Zhang, Yi Quan Zhang. Reciprocal Regulation between Fur and Two RyhB Homologs in Yersinia pestis, and Roles of RyhBs in Biofilm Formation. Biomedical and environmental sciences : BES. 2021 Apr 20;34(4):299-308

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    PMID: 33894809

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