Targets and Mechanisms of Geminivirus Silencing Suppressor Protein AC2.

Geminiviruses are plant DNA viruses that infect a wide range of plant species and cause significant losses to economically important food and fiber crops. The single-stranded geminiviral genome encodes a small number of proteins which act in an orchestrated manner to infect the host. The fewer proteins encoded by the virus are multifunctional, a mechanism uniquely evolved by the viruses to balance the genome-constraint. The host-mediated resistance against incoming virus includes post-transcriptional gene silencing, transcriptional gene silencing, and expression of defense responsive genes and other cellular regulatory genes. The pathogenicity property of a geminiviral protein is linked to its ability to suppress the host-mediated defense mechanism. This review discusses what is currently known about the targets and mechanism of the viral suppressor AC2/AL2/transcriptional activator protein (TrAP) and explore the biotechnological applications of AC2. Copyright © 2021 Veluthambi and Sunitha.

Citation

Karuppannan Veluthambi, Sukumaran Sunitha. Targets and Mechanisms of Geminivirus Silencing Suppressor Protein AC2. Frontiers in microbiology. 2021;12:645419

PMID: 33897657

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