A Comprehensive Landscape for Fibril Association Behaviors Encoded Synergistically by Saccharides and Peptides.

Nature provides us a panorama of fibrils with tremendous structural polymorphism from molecular building blocks to hierarchical association behaviors. Despite recent achievements in creating artificial systems with individual building blocks through self-assembly, molecularly encoding the relationship from model building blocks to fibril association, resulting in controlled macroscopic properties, has remained an elusive goal. In this paper, by employing a designed set of glycopeptide building blocks and combining experimental and computational tools, we report a library of controlled fibril polymorphism with elucidation from molecular packing to fibril association and the related macroscopic properties. The growth of the fibril either axially or radially with right- or left-handed twisting is determined by the subtle trade-off of oligosaccharide and oligopeptide components. Meanwhile, visible evidence for the association process of double-strand fibrils has been experimentally and theoretically proposed. Finally the fibril polymorphs demonstrated significant different macroscopic properties on hydrogel formation and cellular migration control.

Citation

Rongying Liu, Ran Zhang, Long Li, Zdravko Kochovski, Lintong Yao, Mu-Ping Nieh, Yan Lu, Tongfei Shi, Guosong Chen. A Comprehensive Landscape for Fibril Association Behaviors Encoded Synergistically by Saccharides and Peptides. Journal of the American Chemical Society. 2021 May 05;143(17):6622-6633

PMID: 33900761

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