Co-expression Analysis of Genes and Tumor-Infiltrating Immune Cells in Metastatic Uterine Carcinosarcoma.

Runzhi Huang, Hanlin Sun, Gaili Yan, Lili Zhang, Wenhuizi Sun, Jie Zhang, Huabin Yin, Shuyuan Xian, Peng Hu, Penghui Yan, Xiaolong Zhu, Tong Meng, Jun Wang, Zongqiang Huang

Reproductive sciences (Thousand Oaks, Calif.) 2021 Sep

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Uterine carcinosarcoma (UCS) is a malignant tumor with a high tendency to invasion and metastasis. However, the underlying invasion and metastasis mechanisms of UCS remain poorly understood. Genetic alteration and tumor-infiltrating immune cells play important roles in tumorigenesis, progression, and metastasis. To better understand the underlying mechanisms of UCS, we screened tumor-infiltrating immune cells by applying CIBERSORT algorithm and constructed nomograms to predict the prognosis of UCS patients based on metastasis-specific tumor-infiltrating immune cells and genes, and demonstrated their utility by the high AUC values. Combining gene co-expression and experimental validation results, we propose a potential mechanism of AK8, MPZ, and mast cells activated might play important parts in UCS metastasis. © 2021. Society for Reproductive Investigation.

Citation

Runzhi Huang, Hanlin Sun, Gaili Yan, Lili Zhang, Wenhuizi Sun, Jie Zhang, Huabin Yin, Shuyuan Xian, Peng Hu, Penghui Yan, Xiaolong Zhu, Tong Meng, Jun Wang, Zongqiang Huang. Co-expression Analysis of Genes and Tumor-Infiltrating Immune Cells in Metastatic Uterine Carcinosarcoma. Reproductive sciences (Thousand Oaks, Calif.). 2021 Sep;28(9):2685-2698