Correlation Engine 2.0
Clear Search sequence regions


filter terms:
  • azides (3)
  • pyridines (1)
  • Sizes of these terms reflect their relevance to your search.

    A novel copper-catalyzed cyclization of readily available vinyl azides with CF3-ynones is steadily achieved under mild conditions to furnish the versatile 2,4-diaryl-6-trifluoromethylated pyridine products, which are of great interest in medicinal chemistry. The generation of the vinyl iminophosphorane intermediates from vinyl azides through the Staudinger-Meyer reaction ensures the subsequent 1,4-addition process with CF3-ynones in this transformation.

    Citation

    Jixin Wang, Da Ba, Mengqi Yang, Guolin Cheng, Lianhui Wang. Regioselective Synthesis of 2,4-Diaryl-6-trifluoromethylated Pyridines through Copper-Catalyzed Cyclization of CF3-Ynones and Vinyl Azides. The Journal of organic chemistry. 2021 May 07;86(9):6423-6432


    PMID: 33905254

    View Full Text