Acetalated dextran based nano- and microparticles: synthesis, fabrication, and therapeutic applications.

Shiqi Wang, Flavia Fontana, Mohammad-Ali Shahbazi, Hélder A Santos

Chemical communications (Cambridge, England) 2021 Apr 29

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Acetalated dextran (Ac-DEX) is a pH-responsive dextran derivative polymer. Prepared by a simple acetalation reaction, Ac-DEX has tunable acid-triggered release profile. Despite its relatively short research history, Ac-DEX has shown great potential in various therapeutic applications. Furthermore, the recent functionalization of Ac-DEX makes versatile derivatives with additional properties. Herein, we summarize the cutting-edge development of Ac-DEX and related polymers. Specifically, we focus on the chemical synthesis, nano- and micro-particle fabrication techniques, the controlled-release mechanisms, and the rational design Ac-DEX-based of drug delivery systems in various biomedical applications. Finally, we briefly discuss the challenges and future perspectives in the field.

Citation

Shiqi Wang, Flavia Fontana, Mohammad-Ali Shahbazi, Hélder A Santos. Acetalated dextran based nano- and microparticles: synthesis, fabrication, and therapeutic applications. Chemical communications (Cambridge, England). 2021 Apr 29;57(35):4212-4229