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Perforin, a pore-forming glycoprotein, has been demonstrated to play key roles in clearing virus-infected cells and tumour cells due to its ability of forming 'pores' on the cell membranes. Additionally, perforin is also found to be associated with human diseases such as tumours, virus infections, immune rejection and some autoimmune diseases. Until now, plenty of perforin genes have been identified in vertebrates, especially the mammals and teleost fish. Conversely, vertebrate homologue of perforin gene was not identified in the invertebrates. Although recently there have been several reviews focusing on perforin and granzymes in mammals, no one highlighted the current advances of perforin in the other vertebrates. Here, in addition to mammalian perforin, the structure, evolution, tissue distribution and function of perforin in bony fish are summarized, respectively, which will allow us to gain more insights into the perforin in lower animals and the evolution of this important pore-forming protein across vertebrates. © 2021 The Scandinavian Foundation for Immunology.


Jiahui Xu, Ning Yang, Ting Xie, Guiwen Yang, Linrui Chang, Dongchun Yan, Ting Li. Summary and comparison of the perforin in teleosts and mammals: A review. Scandinavian journal of immunology. 2021 Jul;94(1):e13047

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PMID: 33914954

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