A new diarylhexane and two new diarylpropanols from the roots of Knema globularia.

Uraiwan Sriphana, Chavi Yenjai, Jittra Suthiwong, Kitisak Poopasit

Natural product research 2022 Apr

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A new diarylhexane, kneglobularone B (1) and two new diarylpropanols, kneglobularols A - B (2 - 3) along with seven known compounds (4 - 10) were isolated and characterized from the roots of Knema globularia. It is the first time to find arylpropyl quinone (4) and isoflavone (8) in Myristicaceae family. In addition, 5 was found for the first time in Knema genus. Their structures were elucidated by UV, IR, MS, 1 D and 2 D NMR techniques. Compound 4 exhibited strong cytotoxicity against the NCI - H187 and MCF - 7 cell lines with IC50 values of 3.08 and 6.68 µg/mL, respectively.

Citation

Uraiwan Sriphana, Chavi Yenjai, Jittra Suthiwong, Kitisak Poopasit. A new diarylhexane and two new diarylpropanols from the roots of Knema globularia. Natural product research. 2022 Apr;36(7):1741-1748