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S1PR1 signaling in cancer: A current perspective.

B Anu, N N Namitha, K B Harikumar

Advances in protein chemistry and structural biology 2021


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    Sphingosine-1-phosphate receptor 1 (S1PR1) is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P). S1PR1 belongs to the sphingosine-1-phosphate receptor subfamily comprising five members (S1PR1-5). It has prominent roles in regulating endothelial cell cytoskeletal structure, cell migration, immunomodulation, vasculogenesis during embryogenesis, T cell egress and Multiple sclerosis. This review is addressing the role of S1PR1 in tumorigenesis and therapeutic opportunities to target S1PR1 in cancer. Copyright © 2021 Elsevier Inc. All rights reserved.

    Citation

    B Anu, N N Namitha, K B Harikumar. S1PR1 signaling in cancer: A current perspective. Advances in protein chemistry and structural biology. 2021;125:259-274

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    PMID: 33931142

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