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Cancer patients are usually subjected to numerous surgeries during their course of treatment. Recent studies suggest that anesthetic drugs such as propofol, benzodiazepines, and opioids are linked to cognitive impairment. The aim of the study was to show and compare the cognitive function of oncology patients who have undergone surgery and have been sedated with propofol, fentanyl and benzodiazepines. In order to determine whether the cognition of oncological patients is being impaired, a mini-mental state examination (MMSE) test was obtained 6 to 24 hours pre- and postoperatively for the duration of one month from 8 eligible oncological patients and 7 non-oncological ones. Afterwards, the data were statistically processed with SPSS version 25.0 (Chicago, Ill. the USA). The analysis shows that there is statistically significant difference in the preoperative MMSE scores between oncological and non-oncological patients. Oncological patients compound a sensitive group for cognitive dysfunction, and indeed, MMSE test could be useful for cognitive evaluation. The present sample, however, is small, and the results could not be generalized. Therefore a more extensive study is needed. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Alexandrina Nikova, Penelope Vlotinou, Michael Karanikas, Š¢heofilos Tsoleridis, Emmanuil Bakalinis, Vasilios Tselepidis, Konstantinos Ntatsis. Which is the Prognostic Value of the Mini Mental State Examination Test in Surgical Oncology? Folia medica. 2021 Apr 30;63(2):247-252

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PMID: 33932016

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