Pertussis vaccine effectiveness and duration of protection - A systematic review and meta-analysis.

Krista Wilkinson, Christiaan H Righolt, Lawrence J Elliott, Sergio Fanella, Salaheddin M Mahmud

Vaccine 2021 May 27

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A comprehensive review of observational pertussis vaccine effectiveness (VE) studies is needed to update gaps from previous reviews. We conducted a systematic review of VE and duration of protection studies for the whole-cell (wP) and acellular (aP) pertussis vaccines and conducted a formal meta-analysis using random effects models. Evidence continues to suggest that receipt of any pertussis vaccine confers protection in the short-term against disease although this protection wanes rapidly for aP vaccine. We detected significant heterogeneity in pooled estimates due, in part, to factors such as bias and confounding which may be mitigated by study design. Our review of possible sources of heterogeneity may help interpretation of other VE studies and aid design decisions in future pertussis VE research. Copyright © 2021 Elsevier Ltd. All rights reserved.

Citation

Krista Wilkinson, Christiaan H Righolt, Lawrence J Elliott, Sergio Fanella, Salaheddin M Mahmud. Pertussis vaccine effectiveness and duration of protection - A systematic review and meta-analysis. Vaccine. 2021 May 27;39(23):3120-3130