Exploring fruits from genus Prunus as a source of potential pharmaceutical agents - In vitro and in silico study.

Boris M Popović, Bojana Blagojević, Alicja Z Kucharska, Dejan Agić, Nenad Magazin, Maja Milović, Ana Teresa Serra

Food chemistry 2021 Oct 01

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Prunus fruits are recognized to be rich sources of polyphenols with health promoting effect. In this work we evaluated the phenolic profile and bioactivity, namely antioxidant capacity, antiproliferative effect in HT29, and inhibition capacity of α-glucosidase (α-Gls), α-amylase (α-Amy) and human dipeptidyl peptidase III (hDPP III) activities, of traditional Prunus fruits grown in Serbia. Fifteen Prunus samples were investigated and compared: common European plum and three old plum subspecies ('vlaškača', damson plum and white damson), purple-leaf cherry plum, red and white cherry plum, sweet cherry, sweet cherry-wild type, sour cherry, steppe cherry, mahaleb cherry, blackthorn, peach, and apricot. Principal Component Analysis highlighted steppe cherry and blackthorn as Prunus species with the highest bioactive potential. In silico analysis pointed out rutinoside derivatives of cyanidin and quercetin as the most potent inhibitors of α-Gls, α-Amy and hDPP III enzymes. Quercetin 3-O-rutinoside showed the highest binding energy to α-Gls (-10.6 kcal/mol). Copyright © 2021 Elsevier Ltd. All rights reserved.

Citation

Boris M Popović, Bojana Blagojević, Alicja Z Kucharska, Dejan Agić, Nenad Magazin, Maja Milović, Ana Teresa Serra. Exploring fruits from genus Prunus as a source of potential pharmaceutical agents - In vitro and in silico study. Food chemistry. 2021 Oct 01;358:129812