2-Hydroxypropyl-β-cyclodextrin encapsulates dimethyl disulfide producing a controlled release formulation.

Baoqiang Hao, Lirui Ren, Bin Huang, Xiujun Tang, Hongyan Cheng, Dongdong Yan, Yuan Li, Aocheng Cao, Canbin Ouyang, Qiuxia Wang

The Science of the total environment 2021 Jun 15

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Dimethyl disulfide (DMDS), a soil fumigant, is an effective, broad-spectrum compound that often replaces bromomethane (MB) in the prevention and treatment of soil-borne diseases. However, the disadvantages of DMDS include toxicity, volatility, pungent odor, risk of human exposure, and environmental pollution. Cyclodextrin (CD) has been widely used as a carrier of chemicals in many industries due to its functional advantages and safety. In this study, a DMDS-controlled release formulation was developed by encapsulating DMDS in the cavity of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). This formulation reduced DMDS usage and production costs. Orthogonal experimental design, Fourier transform infrared (FT-IR), Scanning electron microscopy (SEM), Thermal gravity analysis (TGA) characterization, efficacy comparison, safety, and other aspects of the evaluation showed that under the best preparation conditions, the encapsulation rate was 81.49%. The efficacy of DMDS@HP-β-CD was similar to unformulated DMDS. The efficacy duration of the formulation was about two times longer than DMDS, and it was safer to use. This study reveals a cyclodextrin-DMDS formulation with reduced toxicity, longer duration, environmental safety and sustainability. Copyright © 2021. Published by Elsevier B.V.

Citation

Baoqiang Hao, Lirui Ren, Bin Huang, Xiujun Tang, Hongyan Cheng, Dongdong Yan, Yuan Li, Aocheng Cao, Canbin Ouyang, Qiuxia Wang. 2-Hydroxypropyl-β-cyclodextrin encapsulates dimethyl disulfide producing a controlled release formulation. The Science of the total environment. 2021 Jun 15;773:145293