Nucleocapsid protein preferentially binds the stem-loop of duplex/quadruplex hybrid that unfolds the quadruplex structure.

Yaping Sheng, Bei Cao, Mingxi Ou, Yu Wang, Siming Yuan, Na Zhang, Taotao Zou, Yangzhong Liu

Chemical communications (Cambridge, England) 2021 May 27

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NCp7 protein binds the duplex/quadruplex hybrid structure, which decreases the thermal stability of DNA and unfolds the G-quadruplex structure. Interestingly, the duplex in the stem-loop region is the more favorable binding site of NCp7. The NCp7 binding twists the top G-tetrad, weakens hydrogen bonding and causes K+ ejection, hence disrupting the G4 structure.

Citation

Yaping Sheng, Bei Cao, Mingxi Ou, Yu Wang, Siming Yuan, Na Zhang, Taotao Zou, Yangzhong Liu. Nucleocapsid protein preferentially binds the stem-loop of duplex/quadruplex hybrid that unfolds the quadruplex structure. Chemical communications (Cambridge, England). 2021 May 27;57(43):5298-5301