SRC-3, a Steroid Receptor Coactivator: Implication in Cancer.

Licen Li, Chu-Xia Deng, Qiang Chen

International journal of molecular sciences 2021 Apr 30

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Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), is a member of the SRC family. SRC-3 regulates not only the transcriptional activity of nuclear receptors but also many other transcription factors. Besides the essential role of SRC-3 in physiological functions, it also acts as an oncogene to promote multiple aspects of cancer. This review updates the important progress of SRC-3 in carcinogenesis and summarizes its mode of action, which provides clues for cancer therapy.

Citation

Licen Li, Chu-Xia Deng, Qiang Chen. SRC-3, a Steroid Receptor Coactivator: Implication in Cancer. International journal of molecular sciences. 2021 Apr 30;22(9)