Molecular Functions of WWOX Potentially Involved in Cancer Development.

Karim Taouis, Keltouma Driouch, Rosette Lidereau, François Lallemand

Cells 2021 Apr 29

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The WW domain-containing oxidoreductase gene (WWOX) was cloned 21 years ago as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The localization of WWOX in a chromosomal region frequently altered in human cancers has initiated multiple current studies to establish its role in this disease. All of this work suggests that WWOX, due to its ability to interact with a large number of partners, exerts its tumor suppressive activity through a wide variety of molecular actions that are mostly cell specific.

Citation

Karim Taouis, Keltouma Driouch, Rosette Lidereau, François Lallemand. Molecular Functions of WWOX Potentially Involved in Cancer Development. Cells. 2021 Apr 29;10(5)