Over-expression of PDE5 in Oral Squamous Cell Carcinoma - Effect of Sildenafil Citrate.

Takahiro Iwasaki, Takeshi Onda, Hirona Honda, Kamichika Hayashi, Takahiko Shibahara, Takeshi Nomura, Masayuki Takano

Anticancer research 2021 May

filter terms:

Phosphodiesterase 5 (PDE5) holds clinical relevance in several pathological states, including lung, breast, and prostate cancer. In this study, we examined PDE5 expression in oral squamous cell carcinoma (OSCC)-derived cell lines and tissues, and the anti-tumour effect of PDE5 inhibitor, sildenafil citrate (SC). Cell proliferation, cell invasion, and gap closure assays were performed in six OSCC-derived cell lines upon treatment with varying concentrations of SC. PDE5 expression was determined in primary OSCC tissues by western blotting and immunohistochemistry. Elevated PDE5 expression was observed in all cell lines. A concentration-dependent decrease in cell viability, invasion rate, and migration was observed after SC treatment. A significant correlation (p=0.05) was observed between elevated PDE5 expression and lymphatic infiltration in OSCC tissues. PDE5 plays an important role in carcinogenesis of OSCC, and the specific inhibition of PDE5 may be an effective chemotherapeutic strategy. Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Citation

Takahiro Iwasaki, Takeshi Onda, Hirona Honda, Kamichika Hayashi, Takahiko Shibahara, Takeshi Nomura, Masayuki Takano. Over-expression of PDE5 in Oral Squamous Cell Carcinoma - Effect of Sildenafil Citrate. Anticancer research. 2021 May;41(5):2297-2306