Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity.

Khamidulla Kamoldinov, Jun Li, Komila Eshbakova, Shamansur Sagdullaev, Gaoya Xu, Yubo Zhou, Jia Li, Haji Akber Aisa

Phytochemistry 2021 Jul

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Phytochemical study on the ethanolic extract of the dried roots of Ferula samarkandica Korovin led to the isolation of nine undiscribed sesquiterpene coumarins, samarcandicins A-I, along with thirteen known sesquiterpene coumarins. Their structures were characterized by detailed spectroscopic analysis including NMR and HR-ESI-MS. Mogoltacin and nevskin exhibited high inhibitory activity against MV-4-11 cell with IC50 values of 3.94 ± 0.06 μM and 3.87 ± 0.10 μM, respectively, and nevskin and feshurin showed high inhibitory activity against mino cell with IC50 values of 1.48 ± 0.06 μM and 7.88 ± 0.60 μM, respectively. Copyright © 2021 Elsevier Ltd. All rights reserved.

Citation

Khamidulla Kamoldinov, Jun Li, Komila Eshbakova, Shamansur Sagdullaev, Gaoya Xu, Yubo Zhou, Jia Li, Haji Akber Aisa. Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity. Phytochemistry. 2021 Jul;187:112705