Correlation Engine 2.0
Clear Search sequence regions

  • cerium (2)
  • cerium oxide (2)
  • gravity (5)
  • homeostasis (2)
  • planarian (3)
  • research (1)
  • stem cell (1)
  • Sizes of these terms reflect their relevance to your search.

    Gravity alterations elicit complex and mostly detrimental effects on biological systems. Among these, a prominent role is occupied by oxidative stress, with consequences for tissue homeostasis and development. Studies in altered gravity are relevant for both Earth and space biomedicine, but their implementation using whole organisms is often troublesome. Here we utilize planarians, simple worm model for stem cell and regeneration biology, to characterize the pathogenic mechanisms brought by artificial gravity alterations. In particular, we provide a comprehensive evaluation of molecular responses in intact and regenerating specimens, and demonstrate a protective action from the space-apt for nanotechnological antioxidant cerium oxide nanoparticles. © 2021 The Authors. Journal of Biomedical Materials Research Part A published by Wiley Periodicals LLC.


    Alessandra Salvetti, Andrea Degl'Innocenti, Gaetana Gambino, Jack J W A van Loon, Chiara Ippolito, Sandra Ghelardoni, Eric Ghigo, Luca Leoncino, Mirko Prato, Leonardo Rossi, Gianni Ciofani. Artificially altered gravity elicits cell homeostasis imbalance in planarian worms, and cerium oxide nanoparticles counteract this effect. Journal of biomedical materials research. Part A. 2021 Nov;109(11):2322-2333

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 33960131

    View Full Text