Serum sickness induced by alemtuzumab in a kidney-pancreas transplant recipient.

Angelito Yango, Bernard Fischbach, Bipin Bista, Richard Ruiz, Hoylan Fernandez, Giuliano Testa

Clinical nephrology 2021 Jul

filter terms:

Serum sickness is an immune-complex-mediated hypersensitivity reaction that was first noted in the early 1900s in patients receiving heterologous antisera, such as horse antitetanus or antidiphtheria serum. This condition is primarily self-limited; however, in its acute state, it can cause severe symptoms of fever, rash, polyarthritis, or polyarthralgias. In solid organ transplantation, this condition is frequently reported in association with the use of rabbit anti-thymocyte globulin and chimeric murine monoclonal antibodies such as rituximab. Alemtuzumab, designed as a humanized monoclonal antibody against CD52, is expected to be less immunogenic. Here, we report a case of serum sickness associated with alemtuzumab induction therapy in a kidney-pancreas dual-organ recipient.

Citation

Angelito Yango, Bernard Fischbach, Bipin Bista, Richard Ruiz, Hoylan Fernandez, Giuliano Testa. Serum sickness induced by alemtuzumab in a kidney-pancreas transplant recipient. Clinical nephrology. 2021 Jul;96(1):47-50