Vaginal Isolates of Candida glabrata Are Uniquely Susceptible to Ionophoric Killer Toxins Produced by Saccharomyces cerevisiae.

Lance R Fredericks, Mark D Lee, Hannah R Eckert, Shunji Li, Mason A Shipley, Cooper R Roslund, Dina A Boikov, Emily A Kizer, Jack D Sobel, Paul A Rowley

Antimicrobial agents and chemotherapy 2021 Jun 17

filter terms:

Compared to other species of Candida yeasts, the growth of Candida glabrata is inhibited by many different strains of Saccharomyces killer yeasts. The ionophoric K1 and K2 killer toxins are broadly inhibitory to all clinical isolates of C. glabrata from patients with recurrent vulvovaginal candidiasis, despite high levels of resistance to clinically relevant antifungal therapeutics.

Citation

Lance R Fredericks, Mark D Lee, Hannah R Eckert, Shunji Li, Mason A Shipley, Cooper R Roslund, Dina A Boikov, Emily A Kizer, Jack D Sobel, Paul A Rowley. Vaginal Isolates of Candida glabrata Are Uniquely Susceptible to Ionophoric Killer Toxins Produced by Saccharomyces cerevisiae. Antimicrobial agents and chemotherapy. 2021 Jun 17;65(7):e0245020