Update on pediatric testicular germ cell tumors.

Testicular germ cell tumors are uncommon tumors that are encountered by pediatric surgeons and urologists and require a knowledge of appropriate contemporary evaluation and surgical and medical management. A review of the recommended diagnostic evaluation and current surgical and medical management of children and adolescents with testicular germ cell tumors based upon recently completed clinical trials was performed and summarized in this article. In this summary of childhood and adolescent testicular germ cell tumors, we review the initial clinical evaluation, surgical and medical management, risk stratification, results from recent prospective cooperative group studies, and clinical outcomes. A summary of recently completed clinical trials by pediatric oncology cooperative groups is provided, and best surgical practices are discussed. Testicular germ cell tumors in children are rare tumors. International collaborations, data-sharing, and enrollment of patients at all stages and risk classifications into active clinical trials will enhance our knowledge of these rare tumors and most importantly improve outcomes of patients with testicular germ cell tumors. This is a review article of previously published and referenced level 1 and 2 studies, but also includes expert opinion level 5, represented by the American Pediatric Surgical Association Cancer Committee. Copyright © 2021. Published by Elsevier Inc.

Citation

Jennifer H Aldrink, Richard D Glick, Reto M Baertschiger, Afif N Kulaylat, Timothy B Lautz, Emily Christison-Lagay, Christa N Grant, Elisabeth Tracy, Roshni Dasgupta, Erin G Brown, Peter Mattei, David H Rothstein, David A Rodeberg, Peter F Ehrlich. Update on pediatric testicular germ cell tumors. Journal of pediatric surgery. 2022 Apr;57(4):690-699

Mesh Tags

PMID: 33975708

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