We report two prints (a woodcut from the 17th century and an engraving from the 18th century) that likely show individuals with PIK3CA-Related Overgrowth Spectrum (PROS). These prints are likely the earliest known depictions of this complex condition. © 2021 Wiley Periodicals LLC.
Thomas F Heyne, Giovanni Neri, Angela E Lin. The earliest depictions of a PIK3CA-Related Overgrowth Spectrum disorder: 17th-18th century prints of women with severe limb overgrowth. American journal of medical genetics. Part C, Seminars in medical genetics. 2021 Jun;187(2):168-172
PMID: 33982378
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