Dimeric Acylphloroglucinol Derivatives with New Skeletons from Leptospermum scoparium.

Kai Xia, Ji-Hong Gu, Xiao-Xue Fu, Ni-Ping Li, Mu Chen, Qian Huang, Wen-Jing Wang, Wen-Cai Ye, Lei Wang

Chemistry & biodiversity 2021 Jun

filter terms:

Leptosparones A-F (1-6), six new dimeric acylphloroglucinol derivatives with unprecedented skeletons, were isolated from Leptospermum scoparium. Compounds 1-3 and 5-6 are phenylpropanoyl-phloroglucinol dimers, while 4 is a phenylpropanoylphloroglucinol-isovalerylphloroglucinol hybrid. Structurally, these compounds represent the first examples of dimeric phloroglucinols with unprecedented C(7')-C(8) linkage between the phloroglucinol core and the acyl side chain. Their structures were elucidated by comprehensive analyses of spectroscopic data, single crystal X-ray diffraction and chemical calculations. In addition, all compounds showed inhibitory effects against α-glucosidase with IC50 values ranging from 39.5 to 186.8 μM. © 2021 Wiley-VHCA AG, Zurich, Switzerland.

Citation

Kai Xia, Ji-Hong Gu, Xiao-Xue Fu, Ni-Ping Li, Mu Chen, Qian Huang, Wen-Jing Wang, Wen-Cai Ye, Lei Wang. Dimeric Acylphloroglucinol Derivatives with New Skeletons from Leptospermum scoparium. Chemistry & biodiversity. 2021 Jun;18(6):e2100252