Human Serum Albumin as Multifunctional Nanocarrier for Cancer Therapy.

Farrukh Zeeshan, Thiagarajan Madheswaran, Jithendra Panneerselvam, Rajeev Taliyan, Prashant Kesharwani

Journal of pharmaceutical sciences 2021 Sep

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Human serum albumin or simply called albumin is a flexible protein employed as a carrier in the fabrication of albumin-based nanocarriers (ANCs) for the administration of cancer therapeutics. Albumin can contribute enhanced tumour specificity, reduced drug induced cytotoxicity and retain concentration of the therapeutically active agent such as drug, peptide, protein, and gene for a prolonged time duration. Nevertheless, apart from cancer management, ANCs are also employed in the diagnosis, imaging, and multimodal cancer therapy. This article figures out salient characteristics, design as well as categories of ANCs in the context of their application in cancer management. In addition, this review article discusses the fabrication methods of ANCs, use of ANCs in gene, cancer, and multimodal therapy along with cancer diagnosis and imaging. Lastly, this review also briefly discusses about (ANCs) formulations, commercial products, and those under clinical testing. Copyright © 2021. Published by Elsevier Inc.

Citation

Farrukh Zeeshan, Thiagarajan Madheswaran, Jithendra Panneerselvam, Rajeev Taliyan, Prashant Kesharwani. Human Serum Albumin as Multifunctional Nanocarrier for Cancer Therapy. Journal of pharmaceutical sciences. 2021 Sep;110(9):3111-3117