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Retrotransposons have been known as major sources of genomic instability that trigger and promote cancer development. In a recent study, Gu et al. revealed that MPP8 deficiency impeded tumor development through reactivation long interspersed element-1 (LINE-1 or L1) retrotransposons in acute myeloid leukemia (AML), suggesting a tumor-suppressive role for retrotransposons. Copyright © 2021 Elsevier Inc. All rights reserved.
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Yangjun Wu, Xiaohua Wu, Shengli Li. Retrotransposons: Jump to Cancer? Trends in cancer. 2021 Jul;7(7):577-579
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PMID: 33992534
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