Tumor necrosis factor alfa in very elderly patients with coronary artery disease.

S V Topolyanskaya, T A Eliseeva, O N Vakulenko, L I Dvoretski

Advances in gerontology = Uspekhi gerontologii 2021

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The results of a study of the concentration of TNF-α as well as the relationship of this cytokine with a number of pathological conditions in very elderly patients with coronary artery disease compared with the control group of patients without CAD are presented in the article. The average group concentration of TNF-α reached 9,2+4,7 pg/ml (from 3,9 to 31,9 pg/ml) with normal TNF-α values of less than 8,1 pg/ml. An increase in the level of TNF-α was detected in 54,6% of patients. In patients with coronary artery disease the average concentration of TNF-α reached 10+4,9 pg/ml, while in the group of patients without CAD - 6,1+1,8 pg/ml (р=0,000001). TNF-α content was higher in patients with chronic heart failure (р=0,002) and with hyperuricemia (р=0,000006). The correlation analysis revealed a significant positive correlation between the level of TNF-α and uric acid (р<0,000001), between the concentration of TNF-α and the content of β-Cross Laps (degradation products of type I collagen) (р=0,0001), as well as serum creatinine (р=0,002) and urea (p=0,00004) levels. In addition, a negative correlation was found between the values of TNF-α and high-density lipoprotein cholesterol concentration (р=0,00005), as well as leptin level (h=0,01). A decrease in the concentration of TNF-а was observed with increasing age of the patients (р=0,006).

Citation

S V Topolyanskaya, T A Eliseeva, O N Vakulenko, L I Dvoretski. Tumor necrosis factor alfa in very elderly patients with coronary artery disease. Advances in gerontology = Uspekhi gerontologii. 2021;34(1):64-70