Non-coding RNAs role in intracranial aneurysm: General principles with focus on inflammation.

Reza Rikhtegar, Pascal J Mosimann, Jan Rothaupt, Mohammad Mirza-Aghazadeh-Attari, Shahin Hallaj, Mehdi Yousefi, Atefeh Amiri, Ebrahim Farashi, Atefeh Kheyrollahiyan, Sanam Dolati

Life sciences 2021 Aug 01

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Intracranial aneurysm (IA) is one of the most challenging vascular lesions in the brain for clinicians. It was reported that 1%-6% of the world's population is affected by IAs. Owing to serious complications arising from these lesions, much attention has been paid to better understand their pathophysiology. Non-coding RNAs including short non-coding RNAs and long non-coding RNAs, have critical roles in modulating physiologic and pathological processes. These RNAs are emerging as new fundamental regulators of gene expression, are related with the progression of IA. Non-coding RNAs act via multiple mechanisms and be involved in vascular development, growth and remodeling. Furthermore, these molecules are involved in the regulation of inflammation, a key process in the formation and rupture of IA. Studying non-coding RNAs can yield a hypothetical mechanism for better understanding IA. The present study aims to focus on the role of these non-coding RNAs in the pathogenesis of IA. Copyright © 2018. Published by Elsevier Inc.

Citation

Reza Rikhtegar, Pascal J Mosimann, Jan Rothaupt, Mohammad Mirza-Aghazadeh-Attari, Shahin Hallaj, Mehdi Yousefi, Atefeh Amiri, Ebrahim Farashi, Atefeh Kheyrollahiyan, Sanam Dolati. Non-coding RNAs role in intracranial aneurysm: General principles with focus on inflammation. Life sciences. 2021 Aug 01;278:119617