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Anti-myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease belongs to a new spectrum of disease entities that cause acute inflammatory demyelinating lesions in the central nervous system. MOG antibody-associated disease presents with several phenotypes including optic neuritis, myelitis, neuromyelitis optica spectrum disorder, brain stem encephalitis, acute disseminated encephalitis, and cortical encephalitis. For the diagnosis, brain magnetic resonance imaging (MRI) and cerebrospinal fluid studies are required to prove inflammatory demyelination apart from the identification of anti-MOG antibodies using cell-based assays. Immunotherapy is an effective treatment strategy to prevent relapse.


Juichi Fujimori, Ichiro Nakashima. Anti-Myelin Oligodendrocyte Glycoprotein Antibody Associated Disease]. Brain and nerve = Shinkei kenkyu no shinpo. 2021 May;73(5):483-488

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PMID: 34006679

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