Clinicopathologic and molecular characterization of melanomas mutated for CTNNB1 and MAPK.

Bénédicte Oulès, Samia Mourah, Barouyr Baroudjian, Fanélie Jouenne, Julie Delyon, Baptiste Louveau, Aurélia Gruber, Céleste Lebbé, Maxime Battistella

Virchows Archiv : an international journal of pathology 2022 Feb

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Wnt/β-catenin signaling plays crucial roles in melanocyte biology and may be implicated in melanoma progression. In this study, we retrospectively examined a real-life cohort of melanomas mutated for β-catenin (CTNNB1), in association or not with a MAPK mutation (of BRAF or NRAS), and analyzed their clinical, histopathological, and molecular characteristics. Our results indicate that, regardless of the presence of a concurrent MAPK mutation, CTNNB1mut cutaneous primary melanomas display more proliferative hallmarks (increased Breslow thickness, mitotic index, and ulceration) than their CTNNB1 wild-type counterparts. Accordingly, they often progress to the metastatic stage. Furthermore, concurrent CTNNB1 and MAPK mutations do not necessarily confer a deep penetrating nevi phenotype. Altogether, this study provides evidence that CTNNB1 mutations in melanomas are associated with specific clinical and pathological features. © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Citation

Bénédicte Oulès, Samia Mourah, Barouyr Baroudjian, Fanélie Jouenne, Julie Delyon, Baptiste Louveau, Aurélia Gruber, Céleste Lebbé, Maxime Battistella. Clinicopathologic and molecular characterization of melanomas mutated for CTNNB1 and MAPK. Virchows Archiv : an international journal of pathology. 2022 Feb;480(2):475-480