DMSA-coated cubic iron oxide nanoparticles as potential therapeutic agents.

Senem Çitoğlu, Özlem Duyar Coşkun, Le Duc Tung, Mehmet Ali Onur, Nguyen Thi Kim Thanh

Nanomedicine (London, England) 2021 May

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Aim: Superparamagnetic cubic iron oxide nanoparticles (IONPs) were synthesized and functionalized with meso-2,3-dimercaptosuccinic acid (DMSA) as a potential agent for cancer treatment. Methods: Monodisperse cubic IONPs with a high value of saturation magnetization were synthesized by thermal decomposition method and functionalized with DMSA via ligand exchange reaction, and their cytotoxic effects on HeLa cells were investigated. Results: DMSA functionalized cubic IONPs with an edge length of 24.5 ± 1.9 nm had a specific absorption rate value of 197.4 W/gFe (15.95 kA/m and 488 kHz) and showed slight cytotoxicity on HeLa cells when incubated with 3.3 × 1010, 6.6 × 1010 and 9.9 × 1010 NP/mL for 24, 48 and 72 h. Conclusion: To the best of our knowledge, this is the first study to investigate both the cytotoxic effects of DMSA-coated cubic IONPs on HeLa cells and hyperthermia performance of these nanoparticles.

Citation

Senem Çitoğlu, Özlem Duyar Coşkun, Le Duc Tung, Mehmet Ali Onur, Nguyen Thi Kim Thanh. DMSA-coated cubic iron oxide nanoparticles as potential therapeutic agents. Nanomedicine (London, England). 2021 May;16(11):925-941