The clinical significance of changes in cTnT, CRP and NT-proBNP levels in patients with heart failure.

This study was designed to explore the clinical significance of changes in troponin T (cTnT), C-reactive protein (CRP) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) levels in patients with heart failure (HF). A total of 193 patients with HF admitted to our hospital from October 2013 to June 2019 were enrolled as the study subjects (group A). Another 191 healthy controls were included as group B. Both groups were compared in terms of cTnT, CRP, NT-proBNP levels and left ventricular ejection fraction (LVEF), and the correlations between LVEF and cTnT, CRP, NT-proBNP were analyzed. The differences in cTnT, CRP, NT-proBNP were compared among patients with different cardiac function, different causes of HF, and between patients with and without cardiac events. cTnT, CRP, and NT-proBNP levels in group A were higher than those in group B (P<0.05). LVEF in group A was lower than that in group B (P<0.05). Negative correlations were found between CRP, cTnT, NT-proBNP and LVEF (P<0.05). As cardiac function improved, cTnT, CRP, NT-proBNP levels also increased, with significant differences between groups (P<0.05). cTnT, CRP, and NT-proBNP levels exhibited no significant difference between the ischemic and non-ischemic HF groups (P>0.05). Patients with cardiac events showed higher levels of cTnT, CRP, and NT-proBNP than those without cardiac events (P<0.05). cTnT, CRP and NT-proBNP levels were elevated in patients with HF, which were negatively correlated with LVEF, and their levels increased with the improvement of cardiac function, independent of the cause of HF. The combination of these three indices is of great significance in the diagnosis and prognosis of HF. AJTR Copyright © 2021.

Citation

Qingsong Wang, Yu An, Hong Wang, Na Zhang, Shuai Deng. The clinical significance of changes in cTnT, CRP and NT-proBNP levels in patients with heart failure. American journal of translational research. 2021;13(4):2947-2954

PMID: 34017460

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