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    Hydroxyapatite (HAp) is the main inorganic component of the bones and teeth, and it possesses bioactivity and biocompatibility. However, due to its poor mechanical performance, slow degradation speed, and lack of diversity in its function, it is difficult to apply HAp alone as a scaffold material for bone tissue engineering. By combining HAp with other types of materials, composite materials with specific properties can be prepared, and the scopes of HAp applications can be expanded. Firstly, we elaborated on the importance, and strengths and weaknesses of HAp for bone tissue engineering biomaterials and then reviewed the research status of HAp composite materials used in bone regeneration. Secondly, about hot research topics in the field of applying HAp composite materials in bone repair, we summarized the representative findings in the field, and discussions and analysis were made accordingly. Finally, we also examined the future development prospects of HAp composite bone repair materials. Copyright© by Editorial Board of Journal of Sichuan University (Medical Sciences).


    Li Wei, Bao-Jin Ma, Jin-Long Shao, Shao-Hua Ge. Advances in the Application of Hydroxyapatite Composite Materials in Bone Tissue Engineering]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2021 May;52(3):357-363

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    PMID: 34018351

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