Role of the ABL tyrosine kinases in the epithelial-mesenchymal transition and the metastatic cascade.

Jillian Hattaway Luttman, Ashley Colemon, Benjamin Mayro, Ann Marie Pendergast

Cell communication and signaling : CCS 2021 May 22

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The ABL kinases, ABL1 and ABL2, promote tumor progression and metastasis in various solid tumors. Recent reports have shown that ABL kinases have increased expression and/or activity in solid tumors and that ABL inactivation impairs metastasis. The therapeutic effects of ABL inactivation are due in part to ABL-dependent regulation of diverse cellular processes related to the epithelial to mesenchymal transition and subsequent steps in the metastatic cascade. ABL kinases target multiple signaling pathways required for promoting one or more steps in the metastatic cascade. These findings highlight the potential utility of specific ABL kinase inhibitors as a novel treatment paradigm for patients with advanced metastatic disease. Video abstract.

Citation

Jillian Hattaway Luttman, Ashley Colemon, Benjamin Mayro, Ann Marie Pendergast. Role of the ABL tyrosine kinases in the epithelial-mesenchymal transition and the metastatic cascade. Cell communication and signaling : CCS. 2021 May 22;19(1):59