LIM domain proteins in cell mechanobiology.

Caitlin A Anderson, David R Kovar, Margaret L Gardel, Jonathan D Winkelman

Cytoskeleton (Hoboken, N.J.) 2021 Jun

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The actin cytoskeleton is important for maintaining mechanical homeostasis in adherent cells, largely through its regulation of adhesion and cortical tension. The LIM (Lin-11, Isl1, MEC-3) domain-containing proteins are involved in a myriad of cellular mechanosensitive pathways. Recent work has discovered that LIM domains bind to mechanically stressed actin filaments, suggesting a novel and widely conserved mechanism of mechanosensing. This review summarizes the current state of knowledge of LIM protein mechanosensitivity. © 2021 Wiley Periodicals LLC.

Citation

Caitlin A Anderson, David R Kovar, Margaret L Gardel, Jonathan D Winkelman. LIM domain proteins in cell mechanobiology. Cytoskeleton (Hoboken, N.J.). 2021 Jun;78(6):303-311