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    An efficient palladium-catalyzed ring-closing reaction of aminodienes with N,O-acetals for the synthesis of saturated N-heterocycles is described. The reaction is consistently operated at room temperature and tolerates a wide range of functional groups with volatile MeOH as the sole byproduct. This method provides rapid and practical access to a broad range of saturated N-heterocycles with diverse structural backbones that are useful building blocks in natural product synthesis and drug discovery.

    Citation

    Bangkui Yu, Suchen Zou, Hanmin Huang. Palladium-Catalyzed Ring-Closing Reaction for the Synthesis of Saturated N-Heterocycles with Aminodienes and N,O-Acetals. The Journal of organic chemistry. 2021 Jun 04;86(11):7849-7863

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    PMID: 34030442

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