Annalisa Montebello, Elizier Zahra Bianco, Darko Babic, Nicholas Paul Delicata, Neville Azzopardi
BMJ case reports 2021 May 25Anterior mediastinal large cell neuroendocrine carcinomas (LCNECs) are extremely rare, extremely aggressive malignancies that carry a dismal prognosis. We discuss a woman aged 60 years who presented with a 2-month history of recurrent severe constant epigastric pain. Abdominal examination revealed massive hepatomegaly and a CT scan of the liver confirmed coarse liver lesions. Histology from a liver biopsy was consistent with a large cell (non-small cell) neuroendocrine carcinoma. A CT scan of the chest showed a large anterior mediastinal mass unrelated to the lung, suggesting that the anterior mediastinum was the primary origin of the tumour. The patient was planned to receive platinum/etoposide chemotherapy for a metastatic mediastinal large cell neuroendocrine carcinoma. Unfortunately, her health deteriorated, and she was unfit to undergo any further treatment. She was treated palliatively and died 2 months after the diagnosis. © BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Annalisa Montebello, Elizier Zahra Bianco, Darko Babic, Nicholas Paul Delicata, Neville Azzopardi. Large cell neuroendocrine carcinoma arising from the anterior mediastinum. BMJ case reports. 2021 May 25;14(5)
PMID: 34035017
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