Quinacrine Treatment of Nitroimidazole-Refractory Giardiasis.

Limited evidence exists on efficacy and tolerability of quinacrine for nitroimidazole-refractory giardiasis. Nitroimidazole-refractory giardiasis cases, defined as microbiologically (microscopy and/or PCR) confirmed treatment failure after 2 courses, during 2008-2020, were retrospectively identified. Of 87 patients, 54 (62%) had visited India. Quinacrine was used in 54 (62%); 51 received monotherapy and 3 combined with metronidazole. Only 3 had positive stool samples with persisting symptoms after quinacrine treatment (94% parasitological efficacy) and all were cured after a second treatment. One (1.9%) had mild adverse effects recorded. Quinacrine is an effective treatment for nitroimidazole-refractory giardiasis with good tolerability. © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.

Citation

Karin A Ydsten, Urban Hellgren, Hilmir Asgeirsson. Quinacrine Treatment of Nitroimidazole-Refractory Giardiasis. The Journal of infectious diseases. 2022 May 16;225(10):1773-1776

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PMID: 34036328

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