Transcatheter Heart Valves: A Biomaterials Perspective.

Heart valve disease is prevalent throughout the world, and the number of heart valve replacements is expected to increase rapidly in the coming years. Transcatheter heart valve replacement (THVR) provides a safe and minimally invasive means for heart valve replacement in high-risk patients. The latest clinical data demonstrates that THVR is a practical solution for low-risk patients. Despite these promising results, there is no long-term (>20 years) durability data on transcatheter heart valves (THVs), raising concerns about material degeneration and long-term performance. This review presents a detailed account of the materials development for THVRs. It provides a brief overview of THVR, the native valve properties, the criteria for an ideal THV, and how these devices are tested. A comprehensive review of materials and their applications in THVR, including how these materials are fabricated, prepared, and assembled into THVs is presented, followed by a discussion of current and future THVR biomaterial trends. The field of THVR is proliferating, and this review serves as a guide for understanding the development of THVs from a materials science and engineering perspective. © 2021 Wiley-VCH GmbH.

Citation

Hieu T Bui, Nipa Khair, Breandan Yeats, Shelley Gooden, Susan P James, Lakshmi Prasad Dasi. Transcatheter Heart Valves: A Biomaterials Perspective. Advanced healthcare materials. 2021 Aug;10(15):e2100115

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PMID: 34038627

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