Magnetic resonance cisternography imaging findings related to the leakage of Gadolinium into the subarachnoid space.

To identify magnetic resonance cisternography (MRC) imaging findings related to Gadolinium-based contrast agent (GBCA) leakage into the subarachnoid space. The number of voxels of GBCA leakage (V-leak) on 3D-real inversion recovery images was measured in 56 patients scanned 4 h post-intravenous GBCA injection. Bridging veins (BVs) were identified on MRC. The numbers of BVs with surrounding cystic structures (BV-cyst), with arachnoid granulations protruding into the superior sagittal sinus (BV-AG-SSS) and the skull (BV-AG-skull), and including any of these factors (BV-incl) were recorded. Correlations between these variables and V-leak were examined based on the Spearman's rank correlation coefficient. Receiver-operating characteristic (ROC) curves were generated to investigate the predictive performance of GBCA leakage. V-leak and the number of BV-incl were strongly correlated (r = 0.609, p < 0.0001). The numbers of BV-cyst and BV-AG-skull had weaker correlations with V-leak (r = 0.364, p = 0.006; r = 0.311, p = 0.020, respectively). The number of BV-AG-SSS was not correlated with V-leak. The ROC curve for contrast leakage exceeding 1000 voxels and the number of BV-incl had moderate accuracy, with an area under the curve of 0.871. The number of BV-incl may be a predictor of GBCA leakage and a biomarker for waste drainage function without using GBCA. © 2021. The Author(s).

Citation

Rei Nakamichi, Toshiaki Taoka, Hisashi Kawai, Tadao Yoshida, Michihiko Sone, Shinji Naganawa. Magnetic resonance cisternography imaging findings related to the leakage of Gadolinium into the subarachnoid space. Japanese journal of radiology. 2021 Oct;39(10):927-937

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PMID: 34050492

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