Proteins Interacting with STIM1 and Store-Operated Ca2+ Entry.

Wen-An Wang, Nicolas Demaurex

Progress in molecular and subcellular biology 2021

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The endoplasmic reticulum (ER) Ca2+ sensor stromal interaction molecule 1 (STIM1) interacts with ORAI Ca2+ channels at the plasma membrane to regulate immune and muscle cell function. The conformational changes underlying STIM1 activation, translocation, and ORAI1 trapping and gating, are stringently regulated by post-translational modifications and accessory proteins. Here, we review the recent progress in the identification and characterization of ER and cytosolic proteins interacting with STIM1 to control its activation and deactivation during store-operated Ca2+ entry (SOCE).

Citation

Wen-An Wang, Nicolas Demaurex. Proteins Interacting with STIM1 and Store-Operated Ca2+ Entry. Progress in molecular and subcellular biology. 2021;59:51-97