Cytotoxic T Lymphocytes (CTLs) and Kidney Transplantation: An Overview.

Federica Rascio, Paola Pontrelli, Giuseppe Grandaliano

Methods in molecular biology (Clifton, N.J.) 2021

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Involvement of T lymphocytes in kidney transplantation is a well-developed topic; however, most of the scientific interest focused on the different type of CD4+ lymphocyte subpopulations. Few authors, instead, investigated the role of CD8+ T cells in renal transplantation and how deleterious they can be to long-term allograft survival. Recently, there has been a renewed interest in the CD8+ T cells involvement in the transplantation field with the aim to investigate the immunological mechanisms underlying the infiltration of CD8+ T cells and their biological functions in human kidney allografts. The purpose of the present review is to highlight the role of allo-reactive cytotoxic T lymphocytes (CTLs) CD8+ subset in allograft kidney recipients and their related clinical complications.

Citation

Federica Rascio, Paola Pontrelli, Giuseppe Grandaliano. Cytotoxic T Lymphocytes (CTLs) and Kidney Transplantation: An Overview. Methods in molecular biology (Clifton, N.J.). 2021;2325:203-213