Biodegradable Dendritic Polyglycerol Sulfate for the Delivery and Tumor Accumulation of Cytostatic Anticancer Drugs.

Mariam Cherri, Magda Ferraro, Ehsan Mohammadifar, Elisa Quaas, Katharina Achazi, Kai Ludwig, Carsten Grötzinger, Michael Schirner, Rainer Haag

ACS biomaterials science & engineering 2021 Jun 14

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Targeted delivery and extended blood circulation of anticancer drugs have been the challenges for decreasing the adverse side effects and improving the therapeutic efficiency in cancer chemotherapy. Herein, we present a drug delivery system (DDS) based on biodegradable dendritic polyglycerol sulfate-bearing poly(caprolactone) (dPGS-PCL) chains, which has been synthesized on 20 g scale using a straightforward two-step protocol. In vivo fluorescence imaging demonstrated a significant accumulation of the DDS in the tumor environment. Sunitinib, an anticancer drug, was loaded into the DDS and the drug-induced toxicity was investigated in vitro and in vivo. The drug encapsulated in dPGS-PCL and the free drug showed similar toxicities in A431 and HT-29 cells, and the cellular uptake was comparable. The straightforward and large-scale synthesis, the organic solvent-free drug-loading approach, together with the tumor targetability of the biodegradable dendritic polyglycerols, render this copolymer a promising candidate for targeted cancer nanomedicine drug delivery systems.

Citation

Mariam Cherri, Magda Ferraro, Ehsan Mohammadifar, Elisa Quaas, Katharina Achazi, Kai Ludwig, Carsten Grötzinger, Michael Schirner, Rainer Haag. Biodegradable Dendritic Polyglycerol Sulfate for the Delivery and Tumor Accumulation of Cytostatic Anticancer Drugs. ACS biomaterials science & engineering. 2021 Jun 14;7(6):2569-2579