Altered expression of EGFR and miR-34a derived from serum and tumoral tissue was associated with glioblastoma multiform.

Glioblastoma multiform (GBM) is the most prevalent and invasive brain malignancy in adults. There are ongoing researches to introduce novel and non-invasive potential biomarkers for the early detection of GBM. Here we compared the expression of EGFR, miR-34a, and miR-19a between tumoral and adjacent non-cancerous tissues (ANCTs) of 50 GBM patients and also compared their expression levels in serum samples of GBM patients with serum samples of 50 control subjects. The expression level of the EGFR gene was elevated in GBM tissues in comparison to the corresponding ANCTs (P < 0.0001) and also was higher in the serum sample of patients compared with control serum (P < 0.0001). The miR-34a was significantly downregulated in serum samples as well as tissues obtained from GBM patients compared with the corresponding controls (expression ratio = 0.57 and 0.4, P = 0.02 and 0.001 respectively). Dysregulation of the EGFR gene and miR-34a in serum samples of GBM patients compared with the control subjects promises the emergence of non-invasive biomarkers for early detection of GBM which need confirmative studies with a large sample size. Copyright © 2021 Elsevier Inc. All rights reserved.

Citation

Samaneh Vojdani, Sayyed Mohammad Hossein Ghaderian, Alireza Zali, Aazadeh Rakhshan, Saeed Oraee Yazdani, Arash Poursheikhani, Farahnaz Bidari Zerehpoush, Giuve Sharifi. Altered expression of EGFR and miR-34a derived from serum and tumoral tissue was associated with glioblastoma multiform. Experimental and molecular pathology. 2021 Aug;121:104655

PMID: 34062187

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