Correlation Engine 2.0
Clear Search sequence regions

  • CD11c (1)
  • cytokines (2)
  • dendritic cells (10)
  • factor (1)
  • interleukin 4 (1)
  • lipoprotein (4)
  • lipoproteins ldl (2)
  • LOX- 1 (8)
  • MAPK (4)
  • marrow (2)
  • mice (1)
  • NF kappa B (2)
  • NF κB (4)
  • oxldl (2)
  • receptors e (2)
  • signal (1)
  • Sizes of these terms reflect their relevance to your search.

    Dendritic cells (DCs) play a crucial role as central orchestrators of immune system response in atherosclerosis initiation and progression. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is involved in the immune maturation of DCs, but the underlying mechanisms remain unclear. We isolated mouse bone marrow progenitors and stimulated them with granulocyte-macrophage colony-stimulating factor and interleukin (IL)-4 to induce immature DCs. We then treated DCs with oxidized low-density lipoprotein (oxLDL) to induce maturation. LOX-1 siRNA was used to investigate the modulation of LOX-1 on the development of DCs and the underlying signal pathways. CD11c-positive DCs were successfully derived from mouse bone marrow progenitors. OxLDL promoted the expressions of DCs maturation markers and pro-inflammatory cytokines. OxLDL also upregulated LOX-1 expression and activated MAPK/NF-κB pathways. LOX-1 siRNA could attenuate the expression of MAPK/NF-κB pathways and inflammatory cytokines. In conclusion, oxLDL induced the maturation of DCs via LOX-1-mediated MAPK/NF-κB pathway, which contributed to the initiation and progression of atherosclerosis.


    D Huang, W Gao, H Lu, J Y Qian, J B Ge. Oxidized low-density lipoprotein stimulates dendritic cells maturation via LOX-1-mediated MAPK/NF-κB pathway. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2021;54(9):e11062

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 34076144

    View Full Text